Safety from High Protein Diet

Sunday, 2 August 2009, 15:17 • 5080 เข้าชมแล้ว
Safety from High Protein Diet

By: Layne Norton

Ever since the day I first touched a weight, I've heard them, the myths surrounding weightlifting and bodybuilding. I'm sure you've heard some of them at one time or another as well. Everything from "weightlifting stunts your growth" to "lifting weights shrinks your penis" to "you know creatine is a steroid, right?"
While many myths are easy to write off as being ridiculous, the myths surrounding protein intake are more widespread. Many people have the impression that high protein diets are unhealthy. Kidney damage, liver damage, heart disease, osteoporosis and others have all been blamed, to some degree, on high protein intakes.

Even the American Heart Association's (AHA) Nutrition Committee stated in 2001 "Individuals who follow these (high protein) diets are at risk for... potential cardiac, renal, bone, and liver abnormalities." Unfortunately for the AHA, there is very little scientific validity to their claim, and much scientific evidence to the contrary.

Myth One

The kidneys are involved in nitrogen excretion, and thus it has been theorized by some that a high nitrogen intake (protein) may cause stress to the kidneys. Additionally, low protein diets have typically been recommended to people who suffer from renal disorders. To conclude that a high protein intake damages the kidney is very tenuous however.
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A study examining bodybuilders with protein intakes of 2.8g/kg vs. well trained athletes with moderate protein intakes revealed no significant differences in kidney function between the groups.1 Additionally, a review of the scientific literature on protein intake and renal function concluded that "there is no reason to restrict protein in healthy individuals."
Furthermore, the review concluded that not only does a low protein intake not prevent the decline in renal function with age, it may actually be the major cause of the decline!2
This conclusion is supported by the fact that the Modification of Diet in Renal Disease (MDRD), did not reveal a low protein diet to be beneficial to blunting the progression of chronic renal failure.3

Myth Two

There is absolutely no evidence to support the notion that a high protein intake is detrimental to the liver. Protein is needed to repair liver tissue and provide methionine for the conversion of fats to lipoproteins so that they may be removed from the liver.4
Amino acids are also the main fuel source for the liver. Additionally, in alcoholic liver disease a high protein diet has been shown to improve liver function and reduce mortality and branch chain amino acids are also being investigated as a treatment for liver disease.5,6
In the case of any tissue that is damaged, protein will be required to repair the damaged tissue. Therefore, a higher than normal intake of protein is needed to provide the amino acids necessary for repair and recovery of the organ.

Myth Three

Another major knock on high protein diets is that they cause increased calcium excretion. Thus a hypothesis stands that over a long period of time, a high protein diet may contribute to the onset of osteoporosis.

What Is Osteoporosis?
A disease in which the bones become extremely porous, are subject to fracture, and heal slowly, occurring especially in women following menopause and often leading to curvature of the spine from vertebral collapse.

However, the real world data is somewhat mixed. Low subject numbers, improper methodology, and several other errors flawed many of the early studies that demonstrated calcium loss due to increased protein intake.7
There is some recent evidence suggesting that an increase in dietary protein may not cause an increase in calcium excretion at all and an increase in dietary protein may potentially improve bone mass in the elderly.8
Moreover, several epidemiological studies actually found a positive association between protein intake and bone mineral density.9,10 Furthermore, low protein diets may actually have a detrimental effect on bone.
Although low protein intakes cause less calcium to be excreted, they also cause a reduction in calcium absorption through the intestine.11 The net effect is a decrease in calcium balance due to a reduction in protein intake.

Myth Four
Heart Disease

Not only does the scientific literature not support the statement that a high protein diet may have a negative impact on the heart, it actually supports a high protein diet for the prevention of heart disease. Recent findings suggest that replacing dietary carbohydrates with protein may decrease the risk of ischaemic heart disease.12

What Is Isischaemic Heart Disease?
Ischaemic Heart Disease, commonly known as Coronary Artery Disease, is a condition in which fatty deposits (atheroma) accumulate in the cells lining the wall of the coronary arteries. This process is called atherosclerosis which leads to narrowing or hardening of the blood vessels supplying blood to the heart muscle.
This results in ischemia (inability to provide adequate oxygen) to heart muscle and this can cause damage to the heart muscle . Complete occlusion of the blood vessel leads to a heart attack (myocardial infarction).

This is supported by the fact that replacing dietary carbohydrates with protein improves blood lipid profiles by decreasing triglyceride levels and increasing HDL (good) cholesterol levels.13
Furthermore, metabolism of carbohydrates and/or fats increases the production of free radical levels to a much greater degree than the metabolism of protein.14 High levels of free radicals are thought to accelerate the formation of atherosclerosis, the major cause of heart disease.15

Diabetes & Weight Loss

A high protein diet may also hold the key to combating obesity and diabetes. Recent research indicates that a diet consisting of 30:40:30 (protein:carbs:fats) was superior to the food guide period diet of 15:55:30 in maintaining glucose homeostasis, increasing insulin sensitivity, and improving glucose control in normal people and those suffering from type II diabetes.13,16,17
This same high protein diet has also been shown to be superior to the food guide pyramid diet for weight loss. Furthermore, subjects consuming the high protein diet maintained more lean muscle tissue and lost a greater proportion of fat than those subjects consuming the high carb diet.17]
Several investigators have also reported increased satiety with the high-protein diet compared to a control high carb diet.18,19 In summary, a high protein, lowered carbohydrate diet is superior to a high carb (i.e. food guide pyramid) diet in promoting fat loss, muscle maintenance, and appetite suppression.

You Can Have Your High Protein Cake & Eat It Too!

Much of this evidence I have presented not only contradicts the statement that high protein diets are unsafe, but supports high protein diets in the prevention/treatment of heart disease, diabetes, and obesity. Those are three of the world's biggest killers, and a high protein diet may be the key to reducing the incidence of all of them!
Perhaps the American Heart Association and the rest of the high protein naysayers would be best served to get the facts first, rather than making statements with little to no scientific support. So next time someone tells you that a high protein diet is bad for you, slide this article on over to them, then sit back and enjoy your next high protein meal.

1.Poortmans JR, Dellalieux O. Do regular high-protein diets have potential health risks on kidney function in athletes? Int J Sports Nutr 2000;10:28-38.
2.Walser M. Effects of protein intake on renal function and on the development of renal disease. In: The Role of Protein and Amino Acids in Sustaining and Enhancing Performance. Committee on Military Nutrition Research, Institute of Medicine. Washington, DC: National Academies Press, 1999, pp. 137-154.
3.Klahr S, Levey AS, Beck GJ et al. The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal failure. N Engl J Med 1994;330:877-884.
4.Navder KP, Lieber CS. Nutrition and alcoholism. In: Bronner, F. ed. Nutritional Aspects and Clinical Management of ChronicDisorders and Diseases. Boca Raton, FL: CRC Press, 2003, pp. 307-320.
5.Mendellhall C, Moritz T, Roselle GA et al. A study of oral nutrition support with oxadrolone in malnourished patients with alcoholic hepatitis: results of a Department of Veterans Affairs Cooperative Study. Hepatology 1993;17:564-576.
6.Suzuki K, Kato A, Iwai M. Branched-chain amino acid treatment in patients with liver cirrhosis. Hepatol Res. 2004 Dec;30S:25-29.
7.Ginty F. Dietary protein and bone health. Proc Nutr Soc 2003;62:867-76.
8.Dawson-Hughes B, Harris SS, Rasmussen H et al. Effect of dietary protein supplements on calcium excretion in healthy older men and women. J Clin Endocrinol Metab 2004;89:1169-73.
9.Geinoz G, Rapin CH, Rizzoli R et al. Relationship between bone mineral density and dietary intakes in the elderly. Osteoporos Int 1993;3:242-8.
10.Cooper C, Atkinson EJ, Hensrud DD et al. Dietary protein intake and bone mass in women. Calcif Tissue Int 1996;58:320-325.
11.Kerstetter JE, Svastislee C, Caseria D et al. A threshold for low-protein-diet-induced elevations in parathyroid hormone. Am J Clin Nutr 2000;72:168-173.
12.Hu FB, Stampfer MJ, Manson JA et al. Dietary protein and risk of ischemic heart disease in women. Am J Clin Nutr 1999;70:221-227.
13.Layman DK, Boileau RA, Erickson DJ, Painter JE, Shiue H, Sather C, Christou DD. A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women. J Nutr. 2003 Feb;133(2):411-7.
14.Mohanty P, Ghanim H, Hamouda W et al. Both lipid and protein intake stimulates increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells. Am J Clin Nutr 2002;75:767-772.
15.Paolisso G, Esposito R, D'Alessio MA, Barbieri M. Primary and secondary prevention of atherosclerosis: is there a role for antioxidants? Diabetes Metab. 1999 Sep;25(4):298-306.
16.Layman DK, Baum JI. Dietary protein impact on glycemic control during weight loss. J Nutr. 2004 Apr;134(4):968S-73S.
17.Layman DK. Protein Quantity and Quality at Levels above the RDA Improves Adult Weight Loss. J Am Coll Nutr. 2004 Dec;23(6 Suppl):631S-6S.
18.Hill AJ, Blundell JE. Composition of the action of macronutrients on the expression of appetite in lean and obese human subjects. Ann N Y Acad Sci. 1990;580:529-31
19.Stubbs RJ, van Wyk MC, Johnstone AM, Barbron CG. Breakfasts high in protein, fat or carbohydrate: effect on within-day appetite and energy balance. Eur J Clin Nutr 1996;50:409-17
My sincerest apologies to Anssi Manninen for not including his peer review article "HIGH-PROTEIN WEIGHT LOSS DIETS AND PURPORTED ADVERSE EFFECTS: WHERE IS THE EVIDENCE?" In my original reference list.
Much information from my article was gleaned from this wonderful peer review and it was also helpful in tracking down other references. Mr. Mannien's article was published in Sports Nutrition Review Journal. 1(1):45-51, 2004. (
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